Many systematic reviews in CF are “empty” i.e. contain no RCTs. Any empty review has the potential to act as a springboard for a clinical trial. This table shows the Cochrane Reviews which have given rise to major RCTs - which are either still ongoing or have been completed and have changed practice. We have identified and summarised the “evidence gaps” in a systematic review which should be the starting point for the next tranche of clinical trials. The review is available here.