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We are an international network of healthcare professionals, researchers and consumers producing systematic reviews of evidence for treating cystic fibrosis and other genetic disorders (haemoglobinopathies. coagulopathies and inborn errors of metabolism). Our editorial base is located in Liverpool, UK.
Standards of care for CFTR variant-specific therapy for people with CF published
We are proud to announce that four of our CF editors and several more of our Group’s contributors, supported by the European Cystic Fibrosis Society, have written and published detailed standards of care for CFTR variant-specific therapy (including modulators) for people with CF. The recently published paper is freely available to access here.
In recent years, therapy tailored to specific variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene has transformed the management of CF and consequently the lives of people living with CF. Taken orally, variant-specific therapy corrects the molecular defect that causes the condition, rather than treating the clinical issues resulting from the condition; thus a relatively simple treatment can greatly ease the treatment burden for those people with CF whose genetic variants can be treated with this therapy. This is still an emerging area of research, but the CFGD Group’s up-to-date Cochrane Reviews underpin the new evidence-based pragmatic guidance for people with CF and their CF teams. The paper also highlights the importance of continued standard treatment for those whose genotypes are as yet ineligible for variant-specific therapy and of continued research to identify and develop therapy for those genotypes.
|Latest output published on The Cochrane Library|
|On Issue 10 2022 of The Cochrane Library we have published a total of 199 reviews and 27 protocols. The production of these reviews involves a network of over 1000 contributors (authors, consumers and referees) throughout the world. We very much welcome interest from new consumers, referees and potential reviewers. Further information can be obtained by contacting the group.|
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